Macro Preparation and Micro Preparations of Diabetes mellitus Patients

Macro preparation and Micro preparations of Diabetes mellitus i.e. Atrophy and lipomatosis of the pancreas, Diabetic nodular glomerulosclerosis

Describe the following macro and micro preparations of Diabetes mellitus Patients

  • Description of the macro preparation:
    1. Which body or part thereof is represented
    2. Surface condition
    3. Sectional view
    4. The condition of the cavities
    5. The prevalence of the process
    6. Conclusion
  • Description of the micro preparation
    1. Which organ tissue is represented
    2. Structural changes
    3. The prevalence of the process
    4. Conclusion

Macro and Micro Preparations of Atrophy and lipomatosis of the pancreas (Diabetes mellitus Patients)

Macro and Micro Preparations of Atrophy and lipomatosis of the pancreas
Atrophy and lipomatosis of the pancreas

 

Description of the macro-preparation of Atrophy and lipomatosis of the pancreas:

  1. Pancrease
  2. Decrease in volume and weight of an organ, lipomatosis and cirrhosis (so-called granular atrophy)
  3. interlayers of whitish connective tissue and areas of lipomatosis.
  4. reduced in size, of dense consistency.
  5. Changes that develop during inflammation, trauma, circulatory disorders, and pancreatic tumors can lead to secondary insulin insufficiency.
  6. In the tissue of the pancreas, a small number of small sclerosed islets of Largenhans, lymphocytic infiltration are determined. The number of β-cells is reduced (picture of type I diabetes); sclerosis and hyalinosis of individual islets of Largenhans are noted, extensive areas of adipose tissue, preserved islets of Langerhans are hypertrophied (picture of type II diabetes)

 

Description of the Micro-preparation of Atrophy and lipomatosis of the pancreas:

  1. Parenchyma, Adipose and connective tissue
  2. small size of parenchymal lobules, proliferation of adipose and connective tissue, preserved single small and often sclerosed islets of Langerhans
  3. Changes that develop during inflammation, trauma, circulatory disorders, and pancreatic tumors can lead to secondary insulin insufficiency.
  4. Atrophy and lipomatosis of the pancreas in type 2 diabetes mellitus

 

 

Macro and Micro Preparations of Diabetic nodular glomerulosclerosis (Diabetes mellitus Patients)

Macro and Micro Preparations of Diabetic nodular glomerulosclerosis
Diabetic nodular glomerulosclerosis

Description of the macro-preparation of Diabetic nodular glomerulosclerosis:

  1. The kidneys in diabetes are affected in the form of diabetic glomerulonephritis and glomerulosclerosis.
  2. Individual microaneurysms, punctate hemorrhages, usually in the periolateral zone, aneurysmal changes in capillaries.
  3. reduced in size, with a fine-grained surface and
  4. dense texture
  5. The prevalence of the process
  6. The long-term presence of the stone leads to sclerosis and atrophy of the renal pelvis, from there the process passes to the interstitial tissue of the kidney, as a result of which the functional elements of the renal parenchyma gradually die and at the same time its fatty substitution occurs.

 

Description of the micro-preparation of Diabetic nodular glomerulosclerosis:

  1. Epithelium & perivascular tissue
  2. the proliferation of mesangial cells, the production of a membrane-like PAS-positive substance, which forms rounded formations in the center of the mesangium & the production of a membrane-like substance by them with the formation of homogeneous eosinophilic rounded formations (SHIK-positive).
  3. development of exudative manifestations of diabetic glomerulopathy in the form of “fibrin caps” and “capsular drops”
  4. dystrophy, proliferation, and then atrophy of endothelial cells, pericytes and myocytes. mast cell reaction in the perivascular tissue.